Abstract

Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field. A wide variety of natural and modified peptides have been obtained and studied, covering multiple therapeutic areas. This review summarizes the efforts and achievements in peptide drug discovery, production, and modification, and their current applications. We also discuss the value and challenges associated with future developments in therapeutic peptides.

Details

Title
Therapeutic peptides: current applications and future directions
Author
Wang, Lei 1 ; Wang Nanxi 2 ; Zhang, Wenping 1 ; Cheng Xurui 1 ; Yan, Zhibin 1 ; Shao Gang 3 ; Wang, Xi 3 ; Wang, Rui 4 ; Fu Caiyun 1   VIAFID ORCID Logo 

1  Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China (GRID:grid.413273.0) (ISNI:0000 0001 0574 8737) 
2  State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, China (GRID:grid.410745.3) (ISNI:0000 0004 1765 1045) 
3  No.903 Hospital of PLA Joint Logistic Support Force, Xi Hu Affiliated Hospital of Hangzhou Medical College, Department of Oncology, Hangzhou, China (GRID:grid.506977.a) (ISNI:0000 0004 1757 7957) 
4  Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou, China (GRID:grid.32566.34) (ISNI:0000 0000 8571 0482); Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
ISSN
20959907
e-ISSN
20593635
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41392-022-00904-4
ProQuest document ID
2628405627
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.