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METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total amount to be prepared.
2. Accurately weigh and/or measure each ingredient.
3. Thoroughly pulverize the required number of sildenafil tablets for the prescription. (A high-speed mill/coffee grinder works well.)
Cream
4. Add the propylene glycol and purified water to the sildenafil citrate powder, and form a smooth paste.
5. Incorporate into sufficient hydrophilic ointment (Dermabase, Vanicream) to final weight and mix well.
6. Package and label.
Gel
7. Mix the sildenafil and methylcellulose powders with the propylene glycol until uniform.
8. Warm the purified water to about 70°C and add to the powder-propylene glycol mixture.
9. Mix well and allow to congeal.
10.Package and label.
PACKAGING
Package in tight, light-resistant containers.1
LABELING
Keep out of reach of children. Use only as directed.
STABILITY
A beyond-use date of 14 days can be used for this preparation when stored in a refrigerator.1
USE
Sildenafil cream and sildenafil gel have been used to improve uterine artery flow and endometrial development in patients undergoing in vitro fertilization.
QUALITY CONTROL
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