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Abstract
The patient's elevated pulmonary-capillary wedge pressure 12 hours after the endotoxin injection and the rapid therapeutic response, with a decrease in heart rate following the administration of furosemide after 44 hours, suggest that the pulmonary edema was more likely a consequence of the positive fluid balance of 15 liters than of a capillary leak. Danner RL, Natanson C, Elin RJ, Pseudomonas aeruginosa compared with Escherichia coli produces less endotoxemia but more cardiovascular dysfunction and mortality in a canine model of septic shock. Anthony F. Suffredini M.D. Robert L. Danner M.D. Yale University School of Medicine, New Haven, CT 06510 Children's Hospital and Medical Center, Seattle, WA 98105 Georgetown University Hospital, Washington, DC 20007 National Institutes of Health, Bethesda, MD 20892