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Abstract
Aim:
To enhance the role of histamine in acute inflammatory reaction
Objective:
Histamine is a vasoactive amine that plays an important role in the early acute inflammatory response. This review enhances the activity of histamine in the acute inflammatory reaction.
Background:
Histamine is stored in the granules of mast cells, basophils, platelets. This histamine is released from these cells by the stimuli inducing acute inflammation, anaphylatoxins, and histamine releasing factors. Histamine increases the vasodilatation, and also increases the vascular permeability in the immediate transient phase of the acute inflammatory reaction. This act as a chemical mediator in acute inflammation.
Keywords- Vasoactive amine, vasodilatation, chemical mediator, mast cells.
INTRODUCTION
Inflammation is a response triggered by damage to living tissues. The inflammatory response is a defense mechanism that evolved in higher inflammation response triggered by damage to living tissues. The inflammatory response is a defense mechanism that evolved in higher organisms to protect them from infection and injury .Its purpose is to localize and eliminate the injurious agent and to remove damaged tissue components so that the body can begin to heal [1] The response consists of changes in blood flow, an increase in permeability of blood vessels, and the migration of fluid, proteins, and white blood cells (leucocytes) from the circulation to the site of tissue damage. An inflammatory response that lasts only a few days is called acute inflammation, while a response of longer duration is referred to as chronic inflammation[1] .Histamine has been established to play a pathophysiological regulatory role in cellular events through binding to four types of G-protein-coupled histamine receptors that are differentially expressed in various cell types. Histamine [2-(4-imidazolyl)-ethylamine] is an endogenous short-acting biogenic amine synthesized from the basic amino acid histidine through the catalytic activity of the rate-limiting enzyme histidine decarboxylase and widely distributed throughout the body. One of the first described functions was its ability to mimic anaphylaxis and has since been demonstrated to play a major role in inflammatory processes [2].Histamine biologically active substance found in a great variety of living organisms. It is distributed widely, albeit unevenly, throughout the animal kingdom and is present in many plants and bacteria and in insect venom. Histamine is chemically classified as an amine, an organic molecule based...