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METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total amount to be prepared.
2. Accurately weigh and/or measure each ingredient.
3. Dissolve the resorcinol and salicylic acid in about 95 mL of isopropyl alcohol 70%.
4. Sprinkle the hydroxypropyl cellulose onto the solution while stirring.
5. Add sufficient isopropyl alcohol 70% to volume and mix well. Allow to set for complete gelling to occur.
6. Package and label.
PACKAGING
Package in tight, light-resistant containers.1
LABELING
Keep out of reach of children. Use only as directed. For external use only.
STABILITY
A beyond-use date of up to 6 months would be appropriate for this preparation.1
USE
Resorcinol and salicylic topical gel has been used in the treatment of acne.
QUALITY CONTROL
Quality-control assessment can include theoretical weight compared to actual weight, pH, specific gravity, active drug assay, color, clarity, texture-surface, texture-spatula spread, appearance, feel, rheological properties and physical observations.2
DISCUSSION
Acne vulgaris is common among both men and women. It may be accompanied by mild soreness, pain or...