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Neuroscience and Behavioral Physiology, Vol. 43, No. 1, January, 2013
Phenotropil Succinate as a Substance Correcting Neuroimmune Impairments in Conditions of Informational-Physical Stress
M. A. Samotrueva,1 I. N. Tyurenkov,2 D. L. Teplyi,3
T. K. Serezhnikova,1 V. M. Berestovitskaya,4
O. S. Vasilieva,4 and S. A. Luzhnova5
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 97, No. 5, pp. 492497, May, 2011. Original article submitted July 3, 2010. Revised version received February 1, 2011.
The psychoimmunomodulatory properties of phenotropil succinate were studied in conditions of experimental informational-physical stress in Wistar rats. Stress was modeled by alternation of two loads: physical (swimming with a load of 10% of body weight as long as could be tolerated) and informational (formation of a food-procuring behavior in a multiple-choice maze) for 20 days. The effects of phenotropil succinate on the specific and nonspecific resistance of the body were studied. Changes in the animals psychoemotional status during exposure to phenotropil succinate were analyzed in the elevated plus maze test and the Porsolt test. The results provide evidence that courses of phenotropil succinate can eliminate neuroimmune impairments developing in conditions of informational-physical stress.
Keywords: phenotropil succinate, neuroimmune correction, information-physical stress.
In recent decades, stress has become a significant object of research in various areas of science: biology, medicine, psychology, and sociology. This is associated with an increase in information loads, decreases in motor activity or, conversely, increases in physical loading and exposure to unfavorable environmental factors influencing somatic and physical health [2, 7]. Mild stressors can be useful, as they activate the bodys protective resources, while long-term or intense stressors lead to their depletion. The development of stress reactions alters the functional activity of various organs and systems, including the central nervous system
and the immune system [1, 11]. Stress-limiting systems play an important role in regulating the bodys stress reactions; one of these is the GABAergic system [5]. Various studies have demonstrated positive influences for gamma-aminobutyric acid (GABA) on immunological processes, in terms of the numbers of antibody-forming and rosette-forming cells and other measures of immunity. Numerous studies have demonstrated the psychomodulatory influences of GABA agonists (phenibut, phenotropil, piracetam), used to combat psychoemotional impairments developing in neuroses, affective processes, and imposition of stress on the body. Thus, studies addressing...