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R E S E A R C H H I G H L I G H T S
PA R A S I T E I N F E C T I O N
Parasite-targeting compound sets identified and ready to go
Compounds targeting the three kinetoplastid parasites most relevant to human disease Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei (which cause visceral leishmaniasis, Chagas disease and sleeping sickness, respectively) have been identified in parallel whole-cell phenotypic assays. The results of this research are publicly available, as are physical samples of the compounds.
The GlaxoSmithKline (GSK) diversity set, which consists of 1.8 million compounds, was first screened for molecules that could inhibit parasite growth in axenic
cultures (L. donovani and T. brucei) or in infected mammalian cells (T. cruzi). The...