Abstract
Dento-facial anomalies and the morpho-functional disorders that occur in the development of the maxillaries have an increasing frequency, a study made by Proffit suggesting that the need for orthodontic treatment in children under the age of 18 in the US would be 60% [1,2]. Over time, many authors have tried to evaluate the malocclusions using different types of indices: diagnosis classification indices, epidemiological indices, success rate of the treatment indices, need for orthodontic treatment indices. By reviewing the literature on this topic, a few controversies aroused regarding the reliability, validity and utility of these indices.
Keywords: orthodontics, evaluation indexes.
1.INTRODUCTION
Occlusal indices are defined as "tools in epidemiological studies, used to determine the need for orthodontic treatment, or the sum of deviations from normal occlusion", which can be used to evaluate patients and population groups where occlusal anomalies are considered to be deviations from the normal occlusion [3]. Diagnostic classification consists in classifying the type of malocclusion as described by Angle, collecting epidemiological data, recording each characteristic of the indices to be applied among the population and thus including epidemiological records of malocclusion. IOTN is the most widely used index to identify the need for treatment and the cut-off point of patients, along with the PAR index, which evaluates the success of the orthodontic treatment.
2.DIAGNOSTIC CLASSIFICATION INDEXES
The classic, original diagnosis of malocclusions was based on the two-dimensional anteriorposterior relationship between the first permanent maxillary and the mandibular molars, a method first described by Angle in 1899. Although intensely criticized, this method remains even today one of the most largely used. Numerous studies analyze the reliability of this method, demonstrating the limits of this classification, starting from the incorrect assumption that the first molars erupt into a constant "key" position (thus ignoring the consequences of migrations or losses of the first molars) [4], continuing with the lack of a threedimensional analysis of malocclusion, which is seen only in the sagital plane [5]. We can also mention other inconveniences, such as: lack of ability to discern the degree of dental health, functional and aesthetic parameters [6]. It also has a poor reproducibility [7-9] and does not take into account the dental relationships related to the facial profile.
Besides Angle's classification, which was applied only for diagnosis purposes [10], other systems are used to establish malocclusion diagnosis, such as the British Standards Institute Classification of 1983 [11], known as based on the relations between the superior and inferior incisors. There have been further attempts to conceive a classification system that includes a three-dimensional evaluation of the dental, skeletal and arch parameters [12]. In conclusion, Angle's classification system has limited applicability in determining the severity of malocclusion, the priority of treatment or its effectiveness.
3.EPIDEMIOLOGICAL INDEXES
Numerous epidemiological indices have been developed for orthodontic examination and, although valuable for traditional planning and research, they remain limited for assessing the priority of access to treatment. For example, an epidemiological tool (facial orthometer) was designed to quantify three components of malocclusion, namely dentition, occlusion and space anomalies [13]. Unfortunately, the complexity of this DFI index restricts its potential clinical applications. Bjork et al. introduced a malocclusion recording system for epidemiological purposes, based on the objective recording of three main occlusal categories: abnormalities in dentition or occlusion and spatial deviations. Using an objective registration procedure, a total number of 567 characteristics was recorded relative to the three categories. Consequently, the complexity of this system restricts its general application [14].The index of tooth position (ITP) was developed as an epidemiological tool [15], based on teeth as individual units, rather than on arch segments, so that dental movement, infra-occlusion, overocclusion are described as the total number of dental malocclusions, obtaining a special malocclusion score. Unfortunately, this epidemiological index is too imprecise to assess the need for treatment for each malocclusion. The misalignment index (MI), based on the discreet evaluation of each arch, divided into two, anterior and posterior segments, tends to underestimate the severity of malocclusion. Subsequent changes have brought little benefits, due to the assessment of tooth movement on a scale of 0 to 2 [16]. Therefore, this index is not appropriate to assess the individual need for treatment. The occlusal feature index (OFI) is based on the main occlusal features important in any orthodontic evaluation [17]: anterior mandibular crowding; intercuspidation, overbite and over jet. The sum of specific deviations from normal determines a global index of malocclusion severity, with values from 0 to 9. OFI scores show reasonable reliability and correlate well with the need for treatment, but they are imprecise in determining the priority of access to orthodontic treatment. The FDI System was developed for COCSTOC in FDI [18]. This system was later evaluated by the World Health Organization (WHO), thus obtaining the Fundamental Method for Classification of WHO / FDI Malocclusions. Created for the clinical examination of patients with all permanent teeth present, this index focuses on three fundamental areas of occlusal assessment: dental, inter-arcade and intra-arcade relationships. Specific features were recorded using coding for various aspects of malocclusion, along with the FDI identification system, so that to locate individual dental malrelations. One of the major impediments of the use of any of the mentioned systems arises from how malocclusion is determined as a single morphological variable [19], which oversimplifies the complexity of malocclusion. Even with trials based on population distributions to identify components that cause malocclusion, the reliability and validity of these derived qualitative systems remain controversial [20].
4.INDICES OF TREATMENT SUCCESS
The success of the orthodontic treatment is dependent on three factors: a correct therapeutical plan, parental consent and support, and patient's cooperation. Several indexes have been developed to evaluate the results of the orthodontic treatments. Eismann [21] devised a method based on the scores assigned to fifteen morphological criteria, which were then summed up to provide a result index of the service. Unfortunately, the attribution of scores was largely subjective, which resulted in the neglect of overall objectivity. Later on, Gottlieb [22] conceived an alternative system, based on ten accepted criteria for orthodontic correction; however this system was inherently influenced by the allocation of five points for a corrected feature, as opposed to allocating only one point for the weakest skill. The Peer review index (PAR), developed as a specific index designed to measure the severity of malocclusion and the success of treatment [23], proved to be a simple tool that does not sacrifice either validity or reliability [24]. In addition, to evaluate the severity of pre-treatment malocclusion, the PAR index was suggested as an index for improving the severity of malocclusion and also for evaluating treatment's success [25,26]. Although considered to be significantly improved, the PAR index appeared as questionable when assessing the North America population, in comparison to the UK one, so that further studies need to be made to establish a consensus in terms of geographical areas [27].
5.INDICES OF TREATMENT NEED IN ORTHODONTICS
In the attempt to classify patient's need for orthodontic treatment, some indices have been developed to provide a method of evaluating treatment priority. Such indices, important in the allocation of financial resources to priority groups [28], are: HLDI- Handicapping Labiolingual Deviation Index [29]; Treatment Priority Index-TPI [30]; Handicapping Malocclusal Record- HMAR [31]; Occlusal Index-OI [32]; Swedish National Board for Health and Welfare [33]; Index of Orthodontic Treatment NeedIOTN [34]; Dental Aesthetic Index - DAI [35].
As to the reliability of TPI, even if it has been confirmed by several studies [36-38], the validity of the index in comparing different degrees of malocclusion remains controversial [39]. HMAR proved the lowest reliability and validity when evaluating the malocclusion severity in comparison to the alternatives HLDI, or OI [39]. Comparatively with other occlusal indices (HMAR, TPI, HLDI), OI showed the highest validity and reproducibility rate [37,39,40], although the absolute validity in relation to the "gold standard" of the consensus of subjective orthodontics remains low [41]. Other deficiencies are: the complexity to use the index [42], the tendency to underestimate the need for treatment [43], the failure to take into account the premature eruption of incisors or loss of molars [6] and the inter-proximal space, except for maxillary diastema over 2 mm [43].
Studies have evidenced the development of a series of occlusal indices for evaluating the need for orthodontic treatment and for quantifying the obtained results, such as: IOTN, with its two components, AC and DHC; DAI - dental aesthetics index; ICON - index for complexity, result and orthodontic necessity, PAR and SCAN - continuously standardized aesthetic necessity index. For all these indices, a weighing system is applied for certain features of malocclusion, reflecting that some deviations of the occlusal components are more important than others in the severity of a malocclusion. In this way, an index can provide an element of flexibility to reflect clinical changes. As the sum of these components reflects the severity of malocclusion, they can be used to analyze treatment priority. Several occlusal indices have been discovered over time, divided by Dr. William Shaw and his colleagues into five different categories: diagnostic indices, epidemiological indices, orthodontic treatment need indices, treatment outcome indices, orthodontic treatment complexity indexes[44]. In order to better exemplify the evolution of occlusal indices, Table 1 presents the classification of occlusal indices, respectively the five categories, indices name, researchers and the year of the discovery of each index. Occlusal indexes are commonly used in countries of Northern Europe, where "the government subsidizes dental health services as well as any part of national health services or national health insurance", in the UK and in 15 US states, but "because of the opinion of the AAO (Orthodontic Association) on the orthodontic indices that not any occlusal index is a valid scientific instrument of the need for orthodontic treatment, the use of occlusal indices in the United States is not encouraged and limited" (Table 1). [45]
Occlusal indices should be able to specifically identify the populations which do not need treatment, and those who need orthodontic treatment (sensitivity). An index must be fast and easy to use, accepted by the population and finally adapted to the existing resources [45]. IOTN is currently used in epidemiological studies due to its reliability, validity and ease of use in both young and adult populations [46]. It has 2 parts: the dental health component and the aesthetic component. The dental health component, based on the Swedish index, looks at the occlusal traits thought to be related to the morbidity of dentition and of the surrounding structures [33]. In the DHC component, for two or more anomalies recorded, only the highest one is recorded [44], as for the AC component only the frontal malocclusion is emphasized [46]. Cons et al. [35] have developed dAi to evaluate the clinical and aesthetic features of dental occlusion, by summing them up, thus obtaining 4 values of malocclusion severity, from minor to very severe. Keay et al. stated that DAI was used in both young and adult dentition, obtaining a higher performance of DAI in permanent dentition, compared to the mixed one [47].
6.CORRELATION BETWEEN THE RELIABILITY AND VALIDITY OF INDEXES
The reliability of DAI and DHC-IOTN was evaluated in a study of Firestone et al. who recorded a good sensitivity for both indexes, poor specificity (IOTN=19%, and DAI=14%), high and similar values for reproducibility, which makes them useful in epidemiological studies. Evaluation time for DAI was higher than for DHC-IOTN, which makes DHC-IOTN a fast implementation index. Firestone observed that ICON is a safe and valid index for treatment need, and also for the complexity and result of orthodontic cases. Sensitivity and specificity were relatively high for ICON. BorzabadiFarahani et al. analyzed ICON and concluded that it is a reliable substitute for DHC-IOTN, indicating a high correlation with it. A similar percentage was observed between these indices - of 89.5%, but also a difference of 10.5% regarding the need for orthodontic treatment. ICON offers several advantages over IOTN, including the ability to assess the complexity of malocclusion and to evaluate treatment outcome [48]. Cons et al. [35] shown that, compared to DAI, ICON is not affected, although it has similar deficiencies due to the lack of evaluation of occlusal anomalies, such as posterior inverse occlusion, tooth damage and deep overbite. Daniels and Richmond concluded that, compared to DAI, ICON registration is significantly easier, taking less time, being therefore suggested as a good substitute for DAI [49]. As other indices, ICON has some limitations: a base on subjective patient opinion, reducing objectivity and affecting the agreements between examiners to evaluate occlusal features of the index [49]. Richmond et al. [23] have specified that the IOTN and PAR indices are valid, against the UK opinion, as they cannot be representative of professional opinions from other countries. Other authors, such as Kerr and Buchanan, in 1993, considered it to be an unjustifiable harsh index in limited-purpose treatment. [50]. Otuyemi and Jones, in 1995, showed that PAR does not take into account periodontal destruction, decalcification, root resorption, dynamic occlusion and facial aesthetics. Although these points are true, there are difficulties in evaluating such reliable parameters, and their importance is questionable when evaluating complex disease cases [51].
7.CONCLUSIONS
There are five important factors to consider when choosing an instrument for assessing the effects of oral health: practical utility, fidelity, validity, objectivity/subjectivity; global/specific measures. When it comes to assessing the treatment needs in a population, three major issues must be pursued: the index must be concise and easy to use in the population within a reasonable time, the assessment scale must be relevant to the decision criteria, and the index must evaluate the variables specified by a model, to provide cause-effect information [52]. Considering the treatment plan and the choice of treatment solutions, the orthodontist also needs to evaluate pain prevention, restoration of the oral functions, maintenance of patient's physiognomy, hygiene and responsibility [53-55]. The conclusion is that there are differences in the validity of the indexes, even though it is not possible to evaluate the degree of validity with the knowledge we have today. IOTN is essentially an epidemiologic tool that has deficiencies in assessing individual cases. The occlusal measurements and the scoring and weighting systems of indexes are conventional. However, our understanding about the consequences of malocclusions has changed since the 1960s. Nowadays, we do not consider as a mandatory orthodontic treatment a patient with caries risk, periodontal disease, and temporomandibular dysfunction. The importance of facial aesthetics and the psychosocial consequences of malocclusions have been and still are widely discussed. In many cases, these may be the most important indicators for orthodontic treatment. However, the American Association of Orthodontists stated in 1990 that it does not recognize any index as a scientifically valid measurement of the need for orthodontic treatment [56]. This statement is still valid, because no new information about the consequences and disadvantages of malocclusions was found in the 1990s.
References
1. Borzabadi-Farahani A, Borzabadi-Farahani A, Eslamipuor F. Malocclusion and occlusal traits in an urban Iranian population: an epidemiological study of 11- to 14-year-old children. Eur J Orthod. 2009; 31:477-84.
2. Cardoso CF, Drummond AF, Lages EM, Pretti H, Ferreira EF, Abreu MH. The Dental Aesthetic Index and Dental Health Component of the Index of Orthodontic Treatment Need as Tools in Epidemiological Studies. Int J Environ Res Public Health. 2011;8(8):3277-86.
3. Hanganu SC, Danilă I. Stomatologie comunitară. Chisinău:Tehnical-Info Press;2002.
4. Chetak S,Sandeep M, Srinivasa H,Krishna N. The Correlation of occlusal indices with patients' perceptions of aesthetics, functions, speech and orthodontic treatment needs. Journal of Dental Sciences and Research. 2010;1(1):22- 40
5. Borzabadi-FarahaniA. An overview of selected orthodontic treatment need indices.In: Naretto S, ed. Principles in Contemporary Orthodontics. Los Angeles:InTech;2011. pp.216-232
6. Pickering EA, Vig P. The occlusal index used to assess orthodontic treatment. Br J Orthod. 1975;2(1):47-51.
7. Katz J, Weinstein E, Barak S, Livneh A. Dental disease in the differential diagnosis of fever of unknown origin. Ann Dent. 1992;51(2):3-5.
8. Rinchuse DJ. Ambiguities of Angle's classification. Angle Orthod. 1989;59(4):295-8.
9. Gravely JF, Johnson DB. Angle's classification of malocclusion: an assessment of reliability. Br J Orthod. 1974;1(3):79-86.
10. Brin I, Camasuvi S, Dali N, Aizenbud D. Comparison of second molar eruption patterns in patients with skeletal Class II and skeletal Class I malocclusions. Am J Orthod Dentofacial Orthop. 2006;130(6):746-51.
11. Abdullah MS, Rock WP. Assessment of orthodontic treatment need in 5,112 Malaysian children using the IOTN and DAI indices. Community Dent Health.2001;18(4):242-8.
12. Proffit WR, Ackerman JL. Rating the characteristics of malocclusion: a systematic approach for planning treatment. Am J Orthod. 1973;64(3):258-69.
13. Pelton WJ, Elsasser WA. Studies of dentofacial morphology. III. The role of dental caries in the etiology of malocclusion. J Am Dent Assoc. 1953;46(6):648-57
14. Bjork A, Krebs A, Solow B. A method for the epidemiological registration of malocclusion. Acta Odontol Scand.1964;22:27-41.
15. Massler M, Frankel JM. Prevalence of malocclusion in children aged 14 to 18 years. Am J Orthod. 1951;37(10):751-68.
16. Van Kirk L Jr. Assessment of malocclusion in population groups. Am J Public Health Nations Health. 1959;49(9):1157-63.
17. Poulton DR, Aaronson SA. The relationship between occlusion and periodontal status. Am J Orthod.1961;4(9)7:690-99.
18. Baume LJ. The pattern of dental disease in French Polynesia. Int Dent J. 1973;23(4):579-84
19. Helm S. Malocclusion in Danish children with adolescent dentition: an epidemiologic study. Am J Orthod.1968;54(5):352-66.
20. Lavelle CL. Study of tooth emergence in British blacks and whites. J Dent.Res. 1976;55(6):1128
21. Eismann D. Reliable assessment of morphological changes resulting from orthodontic treatment. Eur J Orthod. 1979;2(1):19-25.
22. Gottlieb EL. Grading your orthodontic treatment results. J Clin Orthod. 1975;9(3):155- 61.
23. Richmond S, O'Brien K, Buchanan I, Burden D. An Introduction to occlusal indices. Manchester: Mandent Press,;1992.
24. Buchanan IB, Shaw WC, Richmond S, O'Brien KD, Andrews M. A comparison of the reliability and validity of the PAR Index and Summers' Occlusal Index. Eur J Orthod. 1993;15(1):27-31.
25. Richmond S, Shaw WC, Roberts CT, Andrews M. The PAR Index (Peer Assessment Rating): methods to determine outcome of orthodontic treatment in terms of improvement and standards. Eur J Orthod. 1992;14(3):180-7.
26. Richmond S, Andrews M. Orthodontic treatment standards in Norway.Eur J Orthod. 1993;15(1):7-15.
27. DeGuzman L, Bahiraei D, Vig KW, Vig PS, Weyant RJ, O'Brien K. The validation of the Peer Assessment Rating index for malocclusion severity and treatment difficulty. Am J Orthod Dentofacial Orthop. 1995;107(2):172-6..
28. Otuyemi OD, Jones SP. Long-term evaluation of treated class II division 1 malocclusions utilizing the PAR index. Br J Orthod. 1995;22(2):171-8.
29. Parker WS.The HLD (CalMod) index and the index question. Am J Orthod Dentofacial Orthop. 1998;114(2):134-41.
30. Grainger RM. Orthodontic treatment priority index. Vital Health Stat 2. 1967;25:1- 49.
31. Salzmann JA. Handicapping malocclusion assessment to establish treatment priority. Am J Orthod.1968;54(10):749-65.
32. Summers CJ. The occlusal index: a system for identifying and scoring occlusal disorders. Am J Orthod. 1971;59(6):552-67.
33. Linder-Aronson S. Orthodontics in the Swedish Public Dental Health Service. Trans Eur Orthod Soc.1974;233-40
34. Brook PH, Shaw WC. The development of an index of orthodontic treatment priority. Eur J Orthod.1989;11(3):309-20.
35. Cons NC, Jenny J, Kohout F. DAI-the dental aesthetic index. Iowa: College of Dentistry, University of Iowa Press;1986.
36. Popovich F, Thompson GW. A longitudinal comparison of the orthodontic treatment priority index and the subjective appraisal of the orthodontist. J Public Health Dent. 1971;31(1):2-8.
37. Albino JE, Lewis EA, Slakter MJ. Examiner reliability for two methods of assessing malocclusion. Angle Orthod. 1978;48(4):297-302.
38. Lewis DH. Orthodontic problems in the developing occlusion. Angle Orthod. 1978;48(4):297-302.Dent Update. 1982;9(3):145-6, 148-50,152-5.
39. Grewe JM, Hagan DV.Malocclusion indices: a comparative evaluation. Am J Orthod. 1972;61(3):286-94.
40. Hermanson PC, Grewe JM. Examiner variability of several malocclusion indices. Angle Orthod. 1970;40(3):219-25.
41. Scivier GA, Menezes DM, Parker CD.A pilot study to assess the validity of the Orthodontic Treatment Priority Index in English schoolchildren. Community Dent Oral Epidemiol.1974;2(5):246-52.
42. Turner SA.Occlusal indices revisited.Br J Orthod. 1990;17(3):197-203.
43. Tang EL.The prevalence of malocclusion amongst Hong Kong male dental students. Br J Orthod. 1994;21(1):57-63.
44. Hunt O, Hepper P, Johnston C, Stevenson M, Burden D. The aesthetic Component of the Index of Orthodontic Treatment Need validated against lay opinion. Eur J Orthod.2002;24(1):53-9.
45. Kok YV, Mageson P. Comparing a quality of life measure and the Aesthetic Component of the Index of Orthodontic Treatment Need (IOTN) in assessing orthodontic treatment need and concern. J Orthod. 2004;31(4):312-8.
46. Lunn HD. Dental health of 12-year-old children living in similar rural communities in France and England. Int J Paediatr Dent. 1993;3(4):187-92.
47. Keay PA, Freer TJ, Basford KE.Orthodontic treatment need and the dental aesthetic index. Aust Orthod J. 1993;13(1):4-7.
48. Borzabadi-Farahani A, Eslamipuor F. Malocclusion and occlusal traits in an urban Iranian population: an epidemiological study of 11- to 14-year-old children. Eur J Orthod. 2009; 31(5):477-84.
49. Daniels C, Richmond S. The development of the index of complexity, outcome and need (ICON). Journal of Orthodontics.2000;27(2):149-62.
50. Kerr WJ, Buchanan IB, McColl JH.Use of the PAR index in assessing the effectiveness of removable orthodontic appliances. Br J Orthod. 1993;20(4):351-7.
51. Otuyemi OD, Jones SP. Methods of assessing and grading malocclusion: a review. Aust Orthod J. 1995;14(1):21-7.
52. Strauss RP, Hunt RJ. Understanding the value of teeth to older adults: influences on the quality of life. J Am Dent Assoc. 1993;124(1):105-10.
53. Romanec C, Dorobat V, Zetu IN. The autonomous patient and his competence in orthodontics practice. Revista Română de Bioetică.2013;11(3):66-73.
54. Bucur SM, Chibelean M, Păcurar M, Sita DD, Zetu IN. Ethical considerations in orthodontics and dentofacial orthopaedics. Revista Română de Bioetică.2014;12(1):80-84.
55. Beglin FM, Firestone AR, Katherine WL,Vig F,Beck M, Kuthy RA, Wade D. A comparison of the reliability and validity of 3 occlusal indexes of orthodontic treatment need. Am J Orthod Dentofac Orthod.2001;120(3):240-46.
56. Shaw WC, Richmond S, O'Brien KD. The use of occlusal indices-a European perspective. Am J Orthod Dentofacial Orthop. 1995;107(1):1-10.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
© 2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Abstract
Besides Angle's classification, which was applied only for diagnosis purposes [10], other systems are used to establish malocclusion diagnosis, such as the British Standards Institute Classification of 1983 [11], known as based on the relations between the superior and inferior incisors. [...]Angle's classification system has limited applicability in determining the severity of malocclusion, the priority of treatment or its effectiveness. 3.EPIDEMIOLOGICAL INDEXES Numerous epidemiological indices have been developed for orthodontic examination and, although valuable for traditional planning and research, they remain limited for assessing the priority of access to treatment. [...]the complexity of this system restricts its general application [14].The index of tooth position (ITP) was developed as an epidemiological tool [15], based on teeth as individual units, rather than on arch segments, so that dental movement, infra-occlusion, overocclusion are described as the total number of dental malocclusions, obtaining a special malocclusion score. Subsequent changes have brought little benefits, due to the assessment of tooth movement on a scale of 0 to 2 [16]. [...]this index is not appropriate to assess the individual need for treatment.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Ortho. res., PhD, "Grigore T. Popa" University of Medicine and Pharmacy of Iaşi, Romania
2 Univ. Assist., PhD, "Grigore T. Popa" University of Medicine and Pharmacy of Iaşi, Romania
3 Univ. Assist., PhD student, "Grigore T. Popa" University of Medicine and Pharmacy of Iaşi, Romania
4 Lecturer, PhD , "Grigore T. Popa" University of Medicine and Pharmacy of Iaşi, Romania