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Support Care Cancer (2014) 22:20092019 DOI 10.1007/s00520-014-2260-x
REVIEW ARTICLE
Oral and dental late effects in survivors of childhood cancer: a Childrens Oncology Group report
Karen E. Effinger & Cesar A. Migliorati & Melissa M. Hudson &
Kevin P. McMullen & Sue C. Kaste & Kathy Ruble &
Gregory M. T. Guilcher & Ami J. Shah & Sharon M. Castellino
Received: 28 October 2013 /Accepted: 16 April 2014 /Published online: 30 April 2014 # Springer-Verlag Berlin Heidelberg 2014
AbstractPurpose Multi-modality therapy has resulted in improved survival for childhood malignancies. The Childrens Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers provide practitioners with exposure- and risk-based recommendations for the surveillance and management of asymptomatic survivors who are at least 2 years from completion of therapy. This review outlines the pathophysiology and risks for oral and dental late effects in pediatric cancer survivors and the
rationale for oral and dental screening recommended by the Childrens Oncology Group.
Methods An English literature search for oral and dental complications of childhood cancer treatment was undertaken via MEDLINE and encompassed January 1975 to January 2013. Proposed guideline content based on the literature review was approved by a multi-disciplinary panel of survivor-ship experts and scored according to a modified version of the National Comprehensive Cancer Network Categories of Consensus system.
K. E. Effinger (*)
Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Stanford University, 1000 Welch Rd, Suite 300, Palo Alto, CA 94304, USAe-mail: [email protected]
C. A. MiglioratiDepartment of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, 875 Union Ave. Suite N231, Memphis, TN 38163, USA
M. M. HudsonDepartments of Oncology and Epidemiology and Cancer Control, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, Mailstop 735, Memphis, TN 38105, USA
K. P. McMullenDepartment of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Drive, RT 041, Indianapolis, IN 46202, USA
S. C. KasteDepartment of Radiological Sciences, St. Jude Childrens Research Hospital, 262 Danny Thomas Place, MSN 220, Memphis, TN 38105, USA
K. RubleDivision of Pediatric Oncology, John Hopkins School of Medicine, Bloomberg Childrens Center, Room 11368, 1800 Orleans St, Baltimore, MD 21287, USA
G. M. T. GuilcherSection of Paediatric Oncology, Division of Oncology, University of Calgary, 2888 Shaganappi Trail NW, Calgary T3B 6A8, AB,...