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Abstract
Objectives. Mycoplasma hominis and Ureaplasma urealyticum play an important role in the etiology of vaginitis, cervicitis and pelvic inflammatory disease, nongonococcal urethritis, prostatitis, testicular inflammation, urinary stones and infertility. The aim of this study was to demonstrate the rate of incidence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum isolated from urogenital infections in our area.
Methods. By using commercial mycoplasma kit Mycoplasma IES, we investigated their incidence and antimicrobial resistance in patients with genital infection. The samples for testing genital mycoplasmas were collected by picking up vaginal or urethral secretion using sterile Dacron swabs. For men, urine and sperm samples were accepted for diagnostics, according to kit instructions. The culture of genital mycoplasmas was performed by using a commercial mycoplasma kit. The Quality Control was performed with Mycoplasma hominis ATCC 15488.
Results. We examined 2,250 specimens, women (n = 2,084) and men (n = 166), between August-December 2014. Prevalence of positive samples was 16.53% for U. urealyticum (UU) and 1.6% for M. hominis (MH). The median age of the positive patients was 31 years (range: 17-54 years). Among samples positive for UU, 94.6% were sensitive to levofloxacin, 25.6% to ofloxacin and 4,29% to ciprofloxacin. In MH isolates, 100% were sensitive to both levofloxacin and ofloxacin and only 45% to ciprofloxacin. Sensitivity for doxycycline was 86.7%> for UU and 95.45% for MH. Regarding azythromycin, 93.15% UU and 10% MH were sensitive. All 13 male urine samples and 5 sperm samples were negative for UU and MH infections.
Conclusions. In our study, levofloxacin and doxycycline were the most effective drugs for mycoplasma infections. Because of geographical differences among antibiotic resistance, local in-vitro susceptibility testing is recommended to avoid failure of therapy. Surveillance for antibiotic susceptibility is strongly recommended.
Keywords: Mycoplasma hominis, Ureaplasma urealyticum, antibiotic susceptibility, genital infections
Rezumat
Obiective. Mycoplasma hominis si Ureaplasma urealyticum joacà un rol important în etiología vaginitelor, cervicitelor, a bolii inflamatoriipelvine, uretritelor nongonococice, prostatitelor, inflamatiilor la nivel testicular, litiazei urinare si a infertilitâtii. Studiul isi propu ne sà prezinte date cu privire la incidenta si sensibilitatea la antibiotice a tulpinilor izolate de Mycoplasma hominis si Ureaplasma urealyticum de la nivel urogenital.
Metodá. Testarea sensibilitàtii la antibiotice a tulpinilor izolate s-a efectuat folosind kit-ul comercial Mycoplasma IES. Probele examínate au...