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A 60-year-old man, who had diabetes, received lisinopril for hypertension [dosage and route not stated]. He was admitted to hospital 12 days later with generalised erythroderma. A physical examination demonstrated generalised erythroderma with serous drainage involving 90% of his body surface area. Laboratory testing revealed eosinophilia and skin biopsies showed spongiotic dermatitis with mild eosinophilia and psoriasiform acanthosis. He was diagnosed with an adverse drug reaction with underlying psoriasis. Lisinopril was withdrawn and he received prednisone. Within 2 days his erythroderma improved, his prednisone dosage was tapered, and he was discharged from hospital.