Content area
Full Text
British Journal of Cancer (2008) 99, 563 568 & 2008 Cancer Research UK All rights reserved 0007 0920/08 $30.00
http://www.bjcancer.com
Web End =www.bjcancer.com
Human papillomavirus reflex testing as a screening method in cases of minor cytological abnormalities
[notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef] [notdef]
Globally, cervical cancer is the second most common cancer, after breast cancer, among women (Kamangar et al, 2006). Human papillomavirus (HPV) infection is a prerequisite for development of cervical cancer (Bosch et al, 1995; Walboomers et al, 1999). A number of HPV types have been defined as high-risk (HR) HPV (HR-HPV) types, based on their association with cervical cancer (Muoz et al, 2006). However, HPV infection is also common among healthy women. Generally, HPV infection is the most common sexually transmitted infection, and particularly common among young women (Bosch and de Sanjos, 2007). It is usually asymptomatic and spontaneously cleared by the immune system (Franco et al, 1999).
In Sweden, significant decreases in the incidence and mortality of cervical cancer have been observed since the introduction of a population-based gynaecological screening programme in the 1960 s (Bergstrm et al, 1999; Gunnell et al, 2007). However, about 450 new cases of invasive cervical cancer are identified each year. The failure to prevent these cases is due to incomplete screening coverage, inadequate follow-up of abnormal smears, and
M Frberg1,4, B Johansson2, A Hjerpe3 and S Andersson*,11Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden; 2Division of Clinical Virology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden; 3Division of Pathology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm S-141 86, Sweden; 4Centre for Clinical Research (CKF), Uppsala University, Centrallasarettet, Vasters 721 89, Sweden
The aim was to evaluate human papillomavirus (HPV) reflex genotyping in cases of minor cytological abnormalities detected in the gynaecological screening programme in Stockholm, Sweden. Liquid-based cytology samples showing minor cytological abnormalities were analysed using HPV genotyping (Linear Array, Roche diagnostics). Colposcopically directed cervical biopsies were obtained and the HPV test results were correlated with the histological results. In...