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Sarrell EM et al. Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomised, double blind study. Pediatrics & Adolescent Medicine 2006; 160: 197-202.
An alternating treatment regimen of paracetamol (12.5 mg/kg per dose) and ibuprofen (5 mg/kg per dose) every four hours for three days is more effective than monotherapy in lowering fever in infants and children.
Infants and young children are particularly susceptible to fever because of their small body size, high ratio of...