Fenbenzyl and fenbendazole impact on the dog's liver protein synthesizing function during experimental infestation with the pathogen toxocariasis

Abstract

The study aimed to investigate the fenbenzyl and fenbendazole impact on the indicators of the dog's liver protein synthesizing function during experimental infestation with the pathogen toxocariasis. The investigation was performed on 18 dogs, two to four months of age, and three groups of six animals in each were formed: control (C) and two experimental (E-ı, E2). Puppies were experimentally infected with the pathogen toxocariasis at a dose of 5,000 invasive T. canis eggs per kg of body weight. The control dogs were as untreated. Puppies of the (Ei) group were fed the drug "Fenbendazole" at a dose of 150 mg per 3 kg of body weight once a day for three days. Dogs of the (E2) group have applied the "Fenbenzyl" at a dose of 350 mg per 3 kg of body weight once a day for three days. Toxocariasis invasion in canines suppressed the liver protein synthesizing function, indicated by a decrease in total blood protein, albumin fraction, and globulin levels. During fenbendazole treatment for 25 and 30 days, the liver protein synthesizing function was not completely restored, confirmed by the low level of total protein and its albumin fraction. After studying the impact of fenbenzyl on the protein synthesizing function of the liver of dogs infected with Toxocara, a gradual normalization of serum levels of total protein and its fractions was established. The progress of total protein content in the serum of canines of the (E2) group in this period of the trial shows the stimulating effect of milk thistle in the drug "Fenbenzyl" on protein synthesis, compared with the (C) and (E1) groups.