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Bulletin of Experimental Biology and Medicine, Vol. 153, No. 5, September, 2012 PHARMACOLOGY AND TOXICOLOGY
Effects of Tenoten on Anxiety and Depression Disorders in Patients with Epilepsy
A. B. Delger, G. N. Avakyan, O. M. Oleinikova, M. A. Bogomazova, E. A. Chromych, and Iu. V. Lagutin
Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 153, No. 5, pp. 660-663, May, 2012 Original article submitted March 11, 2011
The efciency and safety of tenoten for anxiety and depression disorders in epileptics has been demonstrated. The drug does not change the incidence and severity of epileptic episodes, does not deteriorate the course of the underlying disease, and can be well combined with anti-convulsants. The results indicate the efciency of tenoten used to arrest the anxio-depressive disorders in epilepsy.
Key Words: tenoten; epilepsy; anxiety and depression disorders; ultralow antibody doses; S-100 protein
Anxiety and depression are detected in 6-80% patients with epilepsy [5]. The incidence of episodes with anxio-depressive disorders varies from 3-9% in patients with controlled to 20-55% in patients with continuing attacks [4]. Up to 66% patients feel anxious between the episodes [8]. This variability is explained by a variety of epilepsy forms and its different severity, and differential diagnosis and adequate pathogenetic therapy remain a pressing problem in the majority of cases [3]. Moreover, the incidence of anxiety and depression between the attacks is higher in partial episodes than in generalized ones. This is explained by the fact that the aura (common partial episodes) includes various mental phenomena [7]. Other important factors are the types of episodes, location of the focus of pathological activity, long duration of disease, and early age of disease debut [5,6]. On the other hand, some antiepileptic drugs, used for a long time, are not free from side effects, such as mental changes, amnesia, depressions [1].
The regulatory disorders associated with dopa-mine, glutamate, and GABA play an important role in
the development of anxio-depressive disorders. The GABA-ergic inhibitory systems, playing an important role in the development of anxiety and depression, attract special attention [7]. Tenoten (Materia Medica Holding), containing ultralow dose antibodies to S-100 protein, has exhibited GABA modulating effects and similarly as the neurotrophic factor, plays an important role in the regulation of energy and plastic metabolism in...