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A 25-year-old woman developed acne while receiving duloxetine. The woman, who had been diagnosed with obsessive compulsive disorder (OCD), started receiving duloxetine 60mg once daily [route not stated]. Approximately 4 weeks after starting duloxetine, she developed significant acne breakouts. The woman was treated with antiacnes agents but it was ineffective. Her duloxetine dosage was reduced to 30mg and a significant improvement in her acne was noted; however, her OCD worsened. Her duloxetine dosage was again increased to 60mg and her acne breakouts returned with increased severity [outcome not stated].