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A 59-year-old man developed pancytopenia and bone marrow suppression following concomitant administration of doxycycline for respiratory symptoms from penicillin allergy and methotrexate for rheumatoid arthritis (RA) [routes and duration of treatments to reactions onsets not stated; not all dosage stated].
The man, who had a history of chronic obstructive pulmonary disease and severe RA, presented to hospital for persistent dyspnoea and a productive cough with yellowish sputum. He had been receiving doxycycline on an outpatient basis for respiratory symptoms from a penicillin allergy. Additionally, he was also receiving methotrexate 20 mg/day along with prednisone and leflunomide for RA, which was diagnosed 4-5 years ago. On...