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Web End = Eur J Pediatr (2017) 176:8997 DOI 10.1007/s00431-016-2807-6
http://crossmark.crossref.org/dialog/?doi=10.1007/s00431-016-2807-6&domain=pdf
Web End = ORIGINAL ARTICLE
Diabetes screening in overweight and obese children and adolescents: choosing the right test
Stefan Ehehalt1,4 & Susanna Wiegand2 & Antje Krner3 & Roland Schweizer4 &
Klaus-Peter Liesenktter5 & Carl-Joachim Partsch6 & Gunnar Blumenstock7 &
Ulrike Spielau3 & Christian Denzer8 & Michael B. Ranke4 & Andreas Neu4 &
Gerhard Binder4 & Martin Wabitsch8 & Wieland Kiess3 & Thomas Reinehr9
Received: 11 June 2016 /Revised: 2 November 2016 /Accepted: 4 November 2016 /Published online: 25 November 2016 # Springer-Verlag Berlin Heidelberg 2016
Abstract Type 2 diabetes can occur without any symptoms, and health problems associated with the disease are serious. Screening tests allowing an early diagnosis are desirable. However, optimal screening tests for diabetes in obese youth are discussed controversially. We performed an observational multicenter analysis including 4848 (2668 female) overweight and obese children aged 7 to 17 years without previously
known diabetes. Using HbA1c and OGTT as diagnostic criteria, 2.4% (n = 115, 55 female) could be classified as having diabetes. Within this group, 68.7% had HbA1c levels 48 mmol/mol (6.5%). FPG 126 mg/dl (7.0 mmol/l) and/
or 2-h glucose levels 200 mg/dl (11.1 mmol/l) were found in 46.1%. Out of the 115 cases fulfilling the OGTT and/or HbA1c criteria for diabetes, diabetes was confirmed in
S.E., S.W., and A.K. contributed equally to this work.
Communicated by Beat Steinmann
* Susanna Wiegand [email protected]
Stefan Ehehalt [email protected]
Antje Krner [email protected]
Roland Schweizer [email protected]
Klaus-Peter Liesenktter [email protected]
Carl-Joachim Partsch [email protected]
Gunnar Blumenstock [email protected]
Ulrike Spielau [email protected]
Christian Denzer [email protected]
Michael B. Ranke [email protected]
Andreas Neu [email protected]
Gerhard Binder [email protected]
Martin Wabitsch [email protected]
Wieland Kiess [email protected]
Thomas [email protected]
1 Public Health Department of Stuttgart, Department of Pediatrics,Dental Health Care, Health Promotion and Social Services, Schlostrae 91, 70176 Stuttgart, Germany
2 Department of Pediatric Endocrinology and Diabetes, Charit Childrens Hospital, Universittsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
3 Hospital for Children and Adolescents, Department of Women and Child Health, University Hospitals, University of Leipzig, Liebigstrae 20a, D-04103 Leipzig, Germany
4 Pediatric Endocrinology and Diabetes, University Childrens Hospital, University of Tbingen, Hoppe-Seyler-Str. 1, 72076 Tbingen, Germany
5 Endokrinologikum Berlin am Gendarmenmarkt, Friedrichstrae 76, Jgerstrae 61, 10117 Berlin, Germany
6 Endokrinologikum Hamburg, Lornsenstrae 4-6,...