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ABSTRACT: Crude oil contaminated diet has been reported to induced changes in lipid profile of rats. In this study, 60 albino rats in 6 groups were fed with crude oil contaminated sugar-garri diets at varied concentrations to monitor petroleum-induce lipid profile changes using standard methods. The lipid profiles estimated were total cholesterols, triglycerides, high density lipoprotein cholesterol and Low density lipoproteincholesterol.The data showed that, the levels of total cholesterol (Mmol/l) increased from 2.89±0.08 in sugar fed rats compared with 3.05±0.12 in Gari fed rats. The concentration of triglycerides(Mmol/l) reduced from 1.10±0.51 in sugar fed rats to 1.06 ± 0.03 in Gari fed rats while the high density lipoprotein cholesterol(Mmol/l) concentration of 2. 01±0.08 was significantly higher than 1.89 ± 0.03 in Gari fed rats (P<0.05).There was no significant difference in Low density lipoprotein cholesterol (Mmol/l) concentrations of 0.68±0.11 in sugar fed rats compared with 0.83 ± 0.10 in Gari fed rats. The effect of pre-treatment of the diet with sugar reduced petroleum-induce changes in lipid profile than gari during the exposure of the albino rats to the petroleum diet suggesting that sugarcould possibly ameliorate petroleum-induce changes in lipid profile as shown by the significantlowering of the cholesterol and Low density lipoprotein cholesterol than gari in albino rats. © JASEM

https://dx.doi.org/10.4314/jasem.v21i2.12

Keywords: lipid, Petroleum, Sugar, Gari, Cassava, Changes

Crude oil has been described as a complex mixture of over 6000 potentially different hydrocarbons and metal (Edwards, 1989) and the chemical composition varies between geologic formations (Coppock et al., 1995). Exposure of humans and animal to crude oil, which is increasing in terms of the environmental levels, and application to body, may be toxic. Crude oil is used in folkloric medicine in the Niger-delta area of Nigeria for the treatment of various ailments including stomach up-set, wound, and burns (Orisakwe, et al., 2000). The route of administration is mostly oral and external application for burns and wounds. The ingestion of petroleum hydrocarbon has been reported to induce oxidative stress (Val and Almeida-Val, 1999) through the generation of free radical (Achuba and Osakwe, 2003). It has been established that free radical generation with subsequent oxidative modification leads to lipid peroxidation (Halliwell, 1994) that damages critical cellular macromolecules such as DNA, lipids and proteins (Breimer 1990; Romero et al...

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