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A 74-year-old man receiving diclofenac and colchicine for gouty arthritis developed gastrointestinal toxicity, which progressed to colonic perforation after colchicine was replaced with prednisone.
The man, who had a history of diabetes mellitus, chronic renal failure, ischaemic heart disease, congestive heart failure and hypertension, was diagnosed with gouty ankle arthritis and received diclofenac 100mg [frequency not stated] for pain relief. However, his symptoms did not improve, and second-line therapy with...