Content area
Full Text
Biol Trace Elem Res (2016) 173:108115 DOI 10.1007/s12011-016-0617-3
http://crossmark.crossref.org/dialog/?doi=10.1007/s12011-016-0617-3&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s12011-016-0617-3&domain=pdf
Web End = Coenzyme Q10 Supplementation Prevents Iron Overload While Improving Glycaemic Control and Antioxidant Protectionin Insulin-Resistant Psammomys obesus
Mohamed Amine Lazourgui1 & Salima El-Aoufi1 &
Moussa Labsi2 & Boubekeur Maouche3
Received: 25 October 2015 /Accepted: 4 January 2016 /Published online: 18 January 2016 # Springer Science+Business Media New York 2016
Abstract This study investigated the anti-diabetic preventive activity of coenzyme Q10 (CoQ10) in a murine model of diet-induced insulin resistance (IR), Psammomys obesus (Po). IR was induced by feeding a standard laboratory diet (SD). CoQ10 oil suspension was orally administered at 10 mg/kg body weight (BW)/day along with SD for 9 months. Anthropometric parameters, namely, total body weight gain (BWG) and the relative weight of white adipose tissue (WAT) were determined. Blood glucose, insulin, quantitative insulin sensitivity check index (QUICKI), total antioxidant status (TAS), iron, malondialdehyde (MDA) and nitrite (NO2) were evaluated. NO2 level was also assessed in peripheral blood mononuclear cells (PBMCs) culture supernatants. Our results show that CoQ10 supplementation significantly improved blood glucose, insulin, QUICKI,
TAS, iron and MDA, but influenced neither NO2 levels nor the anthropometric parameters. These findings support the hypothesis that CoQ10 would exert an anti-diabetic activity by improving both glycaemic control and antioxidant protection. The most marked effect of CoQ10 observed in
this study concerns the regulation of iron levels, which may carry significant preventive importance.
Keywords Coenzyme Q10 . Psammomys obesus . Insulin resistance . Diabetes . Antioxidant . Iron
Introduction
Psammomys obesus (Po), often nicknamed sand rat, is a model of nutritionally induced insulin resistance (IR) and type 2 diabetes mellitus (T2DM). This desert gerbil shows IR and develops diet-induced obesity-linked diabetes, initially associated with hyperinsulinaemia and gradually progressing to severe hyperglycaemia [1]. Increasing evidence suggests that oxidative stress plays a key role in the pathogenesis of diabetes mellitus and its complications [2]. Indeed, long-term hyperglycaemia participates in the production of reactive oxygen species (ROS) [3] that affect insulin signalling cascade and transcription of glucose transporters [4], leading to IR. Because of the implication of oxidative stress in the development of diabetes, increasing antioxidant dietary intakes could be of special interest in preventing or delaying onset of the disease.
Coenzyme Q10 (CoQ10), or...