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A 61-year-old woman developed paralytic ileus and constipation during treatment with clozapine, while an interaction between clozapine and fluoxetine increased her serum clozapine concentration; trazodone could have worsened her constipation [routes and some durations of treatments to reaction onsets not stated].
The woman, who had a history of chronic constipation, presented with abdominal pain and distention, nausea and vomiting. She had been receiving clozapine 500 mg/day for 18 years for chronic paranoid schizophrenia, as well as trazodone 25 mg/day and fluoxetine...