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A 23-year-old man developed impaired consciousness, restlessness, hypo-peristalsis and inability to defecate secondary to carbamazepine overdose. Additionally, he concomitantly ingested grapefruit juice, which resulted in an increased blood concentration of carbamazepine leading to its toxicity [duration of treatment to reactions onsets not stated].
The man was transported to the emergency department 2 hours following the ingestion of 100 tablets of carbamazepine 100mg (10g total carbamazepine) along with 1L of 100% grapefruit juice. He had a history of epilepsy, for which he was receiving carbamazepine 200 mg/day. On arrival, he showed signs of restlessness and his Glasgow Coma Scale score was 9. His...