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Two patients experienced symptoms including seizures, respiratory insufficiency, tachycardia, heart arrest, hallucinations, bradycardia, confusion, lethargy and agitation after intentionally overdosing with bupropion. In patient 1, lorazepam-induced respiratory depression may have contributed to a poor outcome.
Patient 1, an 11-year-old girl, was admitted 3.5 hours after ingesting an overdose of slow-release bupropion 6g (167 mg/kg). Two hours after overdosing, she experienced visual hallucinations and agitation; she subsequently developed confusion, lethargy, tachycardia, persistent seizure activity and increased respiration rate. She had been receiving bupropion after being diagnosed with attention deficit...