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Web End = Ann Surg Oncol (2015) 22:33463349 DOI 10.1245/s10434-015-4747-1
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Web End = ORIGINAL ARTICLE BREAST ONCOLOGY
Breast Cancer Risk and Follow-up Recommendations for Young Women Diagnosed with Atypical Hyperplasia and Lobular Carcinoma In Situ (LCIS)
Maureen P. McEvoy, MD, Suzanne B. Coopey, MD, Emanuele Mazzola, PhD, Julliette Buckley, MD, Ahmet Belli, MD, Fernanda Polubriaginof, MD, Andrea L. Merrill, MD, Rong Tang, MD, Judy E. Garber, MD,Barbara L. Smith, MD, PhD, Michele A. Gadd, MD, Michelle C. Specht, MD, Anthony J. Guidi, MD, Constance A. Roche, NP, and Keven S. Hughes, MD
Department of Surgical Oncology-Breast Surgery Division, Massachusetts General Hospital, Boston, MA
ABSTRACTBackground. The risk of breast cancer in young women diagnosed with atypical hyperplasia and (LCIS) is not well dened. The objectives were to evaluate outcomes and to help determine guidelines for follow-up in this population.Methods. A retrospective review of women under age 35 diagnosed with ADH, ALH, LCIS, and severe ADH from 1987 to 2010 was performed. Patient characteristics, pathology and follow-up were determined from chart review.
Results. We identied 58 young women with atypical breast lesions. Median age at diagnosis was 31 years (range 1934). 34 patients had ADH, 11 had ALH, 8 had LCIS, and 5 had severe ADH.7 (12%) patients developed breast cancer. The median follow-up was 86 months (range 1298). Median time to cancer diagnosis was 90 months (range 37231). 4 cancers were on the same side, 3 were contralateral. 4 were IDC, 1 was ILC, and 2 were DCIS.
Cancer was detected by screening mammogram in 4 patients, 2 by clinical exam, and 1 unknown. In the entire cohort, 26 (45%) patients had screening mammograms as part of their follow up, 12 patients had only clinical follow up, and 20 had no additional follow up. 13 patients required subsequent biopsies.
Conclusion. Young women with atypical breast lesions are at a markedly increased risk for developing breast
cancer and should be followed closely. Based on our ndings, we recommend close clinical follow-up, MRI starting at age 25 through age 29, and screening mammo-grams...