Benefit of screening mammography in reducing the rate of late-stage breast cancer diagnoses (United States)

Cancer Causes Control (2006) 17:921929DOI 10.1007/s10552-006-0029-3ORIGINAL PAPERBenefit of screening mammography in reducing the rate

of late-stage breast cancer diagnoses (United States)Sandra A. Norman A. Russell Localio Lan Zhou Anita L. Weber

Ralph J. Coates Kathleen E. Malone Leslie Bernstein Polly A. Marchbanks Jonathan M. Liff Nancy C. Lee Marion R. NadelReceived: 29 January 2006 / Accepted: 4 April 2006

Springer Science+Business Media B.V. 2006AbstractObjective We studied the benefit of modern mammography screening in community settings, evaluatingage-related differences in rates of late-stage breastcancer detection.Methods Our multicenter population-based casecontrol study included 931 black and white womenwith incident breast cancer (American Joint Commission on Cancer Stage IIB or higher) diagnosed 19941998 and 4,016 randomly sampled controls neverdiagnosed with breast cancer. Adjusted odds ratios(ORs) estimated the relative rate of late-stagediagnosis in screened and non-screened women.Results Women aged 5064 at diagnosis with at leastone screening mammogram in the previous 2 yearswere significantly less likely to have late-stage diagnosis (OR = 0.41, 95% CI 0.330.52). Results for women aged 4049 were consistent with a screeningbenefit, although the confidence interval marginallyoverlapped the null (OR = 0.81, 95% CI 0.641.02).Mammography screening was associated with lowerrates of late-stage breast cancer among both premenopausal (OR = 0.64, 95% CI 0.500.81) and postmenopausal (OR = 0.44, 95% CI 0.350.56) women.Conclusions With modern mammography in thecommunity, rates of late-stage breast cancer diagnosesare lower in screened compared to non-screened womenages 40 and older, but age-related differences persist.Keywords Mass screening Mammography Casecontrol studies Breast neoplasms Age groups Premenopause PostmenopauseThe findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers

for Disease Control and Prevention.S. A. Norman (&) A. R. Localio L. Zhou A. L. Weber

Center for Clinical Epidemiology and Biostatistics and

Department of Biostatistics and Epidemiology, University

of Pennsylvania, 801 Blockley Hall, 423 Guardian Drive,

Philadelphia, PA 19104-6021, USAe-mail: [email protected]. ZhouDepartment of Statistics, Texas A&M University, College

Station, TX, USAR. J. Coates N. C. Lee M. R. Nadel

Division of Cancer Prevention and Control, Centers for

Disease Control and Prevention, Atlanta, GA, USAK. E. MaloneFred Hutchinson Cancer Research Center, Seattle, WA,

USAL. BernsteinDepartment of Preventive Medicine, University of Southern

California, Los Angeles, CA, USAP. A. MarchbanksDivision of Reproductive Health, Centers for Disease

Control and Prevention, Atlanta, GA,...