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Abstract
It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.
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1 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Faculty of Medicine, Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany
2 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
3 Telethon Institute for Gene Therapy (SR-Tiget), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy
4 Faculty of Medicine, Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany
5 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II University, Naples, Italy
6 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy; Baylor College of Medicine, Houston, Texas, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, USA
7 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy