Abstract

It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.

Details

Title
TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
Author
A Scotto Rosato 1 ; Montefusco, S 2 ; Soldati, C 2 ; S Di Paola 2   VIAFID ORCID Logo  ; Capuozzo, A 2 ; Monfregola, J 2 ; Polishchuk, E 2 ; Amabile, A 3 ; Grimm, C 4 ; Lombardo, A 3   VIAFID ORCID Logo  ; De Matteis, M A 5   VIAFID ORCID Logo  ; Ballabio, A 6   VIAFID ORCID Logo  ; Medina, D L 7   VIAFID ORCID Logo 

 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Faculty of Medicine, Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany 
 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy 
 Telethon Institute for Gene Therapy (SR-Tiget), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy 
 Faculty of Medicine, Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität, Munich, Germany 
 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II University, Naples, Italy 
 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy; Baylor College of Medicine, Houston, Texas, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, USA 
 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy 
Pages
1-16
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2323449802
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.