Teljes szöveg

Kapcsolja be a keresési kifejezés váltást

© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Absztrakt

Phlai (Zingiber montanum) has long been valued for its anti-inflammatory and analgesic properties in traditional medicine. This study aimed to develop and assess the physical stability, chemical composition, and clinical efficacy of a novel Phlai spray cool formula (PSCF) compared to a diclofenac spray (DS) in patients with chronic myofascial pain syndrome. The chemical analysis revealed curcumin (28.73 ± 5.73 mg/100 g), β-sitosterol (50.92 ± 1.27 mg/100 g), and lauric acid (38.86 ± 1.72 g/100 g) as key active compounds. PSCF demonstrated stable physicochemical properties, including pH and peroxide value across storage conditions. In a randomized controlled trial involving 66 participants, PSCF and DS groups exhibited comparable reductions in pain intensity, as measured by the Visual Analog Scale (VAS), from baseline to week 2. Both groups also showed significant improvements in neck disability index (NDI), pressure pain threshold (PPT), and cervical range of motion (CROM). By week 2, the increase in CROM for flexion and extension reached 23.54 ± 4.09° and 19.43 ± 3.20°, respectively, with no significant intergroup differences. The SF-36 health survey indicated notable improvements in overall health status and quality of life, particularly in physical and emotional domains. The analgesic effects of PSCF are attributed to the combined action of menthol, β-sitosterol, and curcumin. The study demonstrated that PSCF offers a therapeutic effect comparable to diclofenac spray without adverse reactions, highlighting its potential as an alternative topical analgesic for chronic myofascial pain management.

Részletek

Cím
Efficacy of Phlai (Zingiber montanum) Spray Cool Formula in Managing Upper Trapezius Myofascial Pain Syndrome: A Randomized Controlled Trial
Szerző
Tunit, Prakairat 1   VIAFID ORCID logó  ; Mahama, Nurmee 1 ; Nursawiyah Mina 1 ; Chi, Nasrin 1 ; Maenpuen, Suwanna 2   VIAFID ORCID logó  ; Sawangwong, Pornchai 3 ; Hemtong, Waratta 1 ; Sirited, Phasit 4 ; Chittasupho, Chuda 5   VIAFID ORCID logó 

 Thai Traditional Medicine Program, Faculty of Nursing and Allied Health Sciences, Phetchaburi Rajabhat University, Phetchaburi 76000, Thailand; prakairat.tun@mail.pbru.ac.th (P.T.); nurmee7783@gmail.com (N.M.); nursawiyamina@gmail.com (N.M.); nasrin.chi@mail.pbru.ac.th (N.C.); waratta.hem@mail.pbru.ac.th (W.H.) 
 Applied Thai Traditional Medicine Program, Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand; suwanna.m@msu.ac.th 
 Thai Traditional and Integrated Medicine Hospital, Department of Thai Traditional and Alternative Medicine, Ministry of Public Health, Nonthaburi 11000, Thailand; pornchai093@gmail.com 
 Public Health Program, Faculty of Nursing and Allied Health Sciences, Phetchaburi Rajabhat University, Phetchaburi 76000, Thailand; phasit2530@gmail.com 
 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand 
Első oldal
360
Publikáció éve
2025
Publikáció dátuma
2025
Kiadó
MDPI AG
e-ISSN
20751729
Forrástípus
Tudományos folyóirat
Publikáció nyelve
English
ProQuest dokumentumazonosító
3181528144
Copyright
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.