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Abstract
The association between concentration of cortisol over the preceding 3 months and depression was evaluated in patients with coronary artery disease attending a cardiac rehabilitation program. Two groups of participants were recruited: 1 group at entry (22 depressed, 64 non-depressed), and another at completion of the one year program (15 depressed, 28 non-depressed). Both groups were assessed for depressive symptoms and provided a 20 mg hair sample. After controlling for age and gender, ANCOVA showed a positive association between cortisol and depression in patients finishing rehabilitation program; however, no association was found in patients starting rehabilitation. Linear regression showed no significant association between concentrations of cortisol and measures of stress. If confirmed in a larger sample of patients, sustained HPA axis activation may be associated with lack of improvement in depression in CAD patients despite attending a 1 year program. Treatment targeting the HPA axis may be warranted.
