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ABSTRACT:
Introduction: Acne vulgaris is a common skin disorder characterized by non-inflammatory and inflammatory lesions. The current therapy has severe side effects, therefore needs alternative therapy to treat such disease. Objective: This study has been taken to investigate in vitro anti-acne activity of Azardirachta indica Linn., Glycyrrhiza glabra Linn., and Ocimum basilicum Linn.extract and its oil. Materials and Methods: In this study, different extracts and its oil were evaluated against the Propionibacterium acne, Staphylococcus epidermidis by agar well diffusion method. Tetracycline disc and dalacinTM (1%clindamycin phosphate solution) were taken as positive control. Result and Conclusion: Ocimum basilicum extract showed significant activity but the anti-acne activity shown by its oil is comparatively greater than Ocimum basilicum extract. Azardirachta indica ethanol fraction showed greater activity as compared to Azadirachta indica ethanol extract, and the Azardirachta indica chloroform fraction, pet ether fraction and ethyl acetate fraction showed moderate action. Hence from the study it can be concluded that basil oil, ethanolic extract of neem can be used for the treatment of acne vulgaris.
KEYWORDS: Acne vulgaris, P.acne, Azrdirachta indica Linn., Glycyrrhiza glabra Linn., Ocimum basilicum Linn.
INTRODUCTION:
Acne vulgaris is a common skin disorder affecting more than 85% of patients in the United States alone. It is not a lethal or debilitating disorder but can be painful and disfiguring, causing significant physiological distress and heavy economic burden. It is associated with increase in anxiety, depression, and suicidal ideation (1). It is the most common skin disease in the world, and the number of antibiotics resistant to acne inducing bacterial strains has been increasing in the past years. Therefore natural substances from plants may be promising candidates to treat this disease (2).
Current treatments of acne vulgaris fall into two categories: topical or oral. Common topical treatments include benzoyl peroxide, retinoids, and antibiotics (i.e., erythromycin or clindamycin), and common oral treatments include retinoids and antibiotics (i.e., tetracycline and macrolides). In cases of severe acne, combinational treatments are used, usually employing benzoyl peroxide, retinoids, and/or antibiotics together. Antibiotics have been used for over 50 years to treat acne and today one course of topical or systemic treatment typically lasts 3-6 month (3).
Antibiotics are thought to inhibit inflammation indicative of acne when used topically and systemically, as well as...