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Abstract
The adult mammalian brain possesses the remarkable capacity for generating new neurons throughout life. Adult mouse hippocampal neurogenesis is thought to recapitulate many hallmarks of neurodevelopment and occurs in a spatially-defined, temporally-dilated manner. Because the mature central nervous system context is often thought of as inhospitable to cell growth or genesis, it is important to understand how the complex adult neurogenesis and neurodevelopmental processes can occur, and in what ways these processes may differ from those of embryonic neurogenesis. The thesis research presented here examines how adult mouse hippocampal neurogenesis occurs at a cellular level throughout neural development from stem cell to nerve cell. (Abstract shortened by ProQuest.)
