A new volar plate made of carbon-fiber-reinforced polyetheretherketon for distal radius fracture: analysis of 40 cases

Abstract

Implants based on the polyetheretherketon (PEEK) polymer have been developed in the last decade as an alternative to conventional metallic devices. PEEK devices may provide several advantages over the use of conventional orthopedic materials, including the lack of metal allergies, radiolucency, low artifacts on magnetic resonance imaging scans and the possibility of tailoring mechanical properties. The purpose of this study was to evaluate the clinical results at 12-month follow-up using a new plate made of carbon-fiber-reinforced polyetheretherketon for the treatment of distal radius fractures.

We included 40 consecutive fractures of AO types B and C that remained displaced after an initial attempt at reduction. The fractures were classified according to the AO classification: 21 fractures were type C1, 9 were type C2, 2 were type C3, 2 were type B1 and 6 were type B2.

At a 12-month follow-up no cases of hardware breakage or loss of the surgically achieved fracture reduction were documented. All fractures healed, and radiographic union was observed at an average of 6 weeks. The final Disabilities of Arm, Shoulder and Hand score was 6.0 points. The average grip strength, expressed as a percentage of the contralateral limb, was 92 %. Hardware removal was performed only in one case, for the occurrence of extensor tenosynovitis.

At early follow-up this device showed good clinical results and allowed maintenance of reduction in complex, AO fractures.

Therapeutic IV.

J Orthopaed Traumatol (2014) 15:277283 DOI 10.1007/s10195-014-0311-1

ORIGINAL ARTICLE

A new volar plate made of carbon-ber-reinforced polyetheretherketon for distal radius fracture: analysis of 40 cases

Luigi Tarallo Raffaele Mugnai Roberto Adani

Francesco Zambianchi Fabio Catani

Received: 23 November 2013 / Accepted: 27 June 2014 / Published online: 15 July 2014 The Author(s) 2014. This article is published with open access at Springerlink.com

AbstractBackground Implants based on the polyetheretherketon (PEEK) polymer have been developed in the last decade as an alternative to conventional metallic devices. PEEK devices may provide several advantages over the use of conventional orthopedic materials, including the lack of metal allergies, radiolucency, low artifacts on magnetic resonance imaging scans and the possibility of tailoring mechanical properties. The purpose of this study was to evaluate the clinical results at 12-month follow-up using a new plate made of carbon-ber-reinforced polyetheretherketon for the treatment of distal radius fractures. Materials and methods We included 40 consecutive fractures of AO types B and C that remained displaced after an initial attempt at reduction. The fractures were classied according to the AO classication: 21 fractures were type C1, 9 were type C2, 2 were type C3, 2 were type B1 and 6 were type B2.

Results At a 12-month follow-up no cases of hardware breakage or loss of the surgically achieved fracture reduction were documented. All fractures healed, and radiographic union was observed at an average of 6 weeks. The nal Disabilities of Arm, Shoulder and Hand score was6.0 points. The average grip strength, expressed as a percentage of the contralateral limb, was 92 %. Hardware

removal was performed only in one case, for the occurrence of extensor tenosynovitis.

Conclusion At early follow-up this device showed good clinical results and allowed maintenance of reduction in complex, AO fractures.

Type of study/level of evidence Therapeutic IV.

Keywords DiPHOS Plate Radius Fracture PEEK

Radiolucent Carbon-ber-reinforced

Introduction

Open reduction and internal xation using pre-contoured plates has become a surgical treatment option for displaced, unstable and comminuted fractures of the distal radius. They provide immediate stable xation allowing early mobilization, which can result in rapid recovery and improved regain of function [1, 2]. Fixed angle plates using locking-screw technology allow surgeons to manage complex periarticular fractures since they give distal stability by direct support of the subchondral bone and do not depend on distal screw purchase to maintain reduction [1].

Distal radius plating can be performed using a dorsal or volar approach; however, a higher rate of tendon irritation and rupture has been reported with the use of dorsal plates [3]. Implants based on the polyetheretherketon (PEEK) polymer have been developed in the last decade as an alternative to conventional metallic devices. PEEK devices may provide several advantages over the use of conventional orthopedic materials, including the lack of metal allergies, radiolucency, low artifact interference on magnetic resonance imaging scans and the possibility of tailoring mechanical properties [4]. In fact, compared with clinically used metallic implants, CFR-PEEK implants can

L. Tarallo (&) R. Mugnai F. Zambianchi F. Catani

Orthopaedics and Traumatology Department, Modena Policlinic, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124 Modena, Italye-mail: [email protected]

R. AdaniDepartment of Hand Surgery and Microsurgery, University Hospital of Verona, Verona, Italy

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be designed with more appropriate strength, toughness, or stiffness by the arrangement of reinforcing ber volume and orientation, and can provide better fatigue resistance [5].

Although neat (unlled) PEEK biomaterials can exhibit an elastic modulus ranging between 3 and 4 GPa, the modulus can be tailored to closely match cortical bone(18 GPa) or titanium alloy (110 GPa) by preparing carbon-ber-reinforced (CFR) composites with varying ber length and orientation [6]. Therefore, PEEK has a more similar stiffness to bone than titanium.

A recent study compared the CFR-PEEK dynamic compression plate, distal radius volar plate, proximal humeral plate, and tibial nail to commercially available devices regarding the biomechanical characteristics (by four-point bending, static torsion of the nail, and bending fatigue) and the wear/debris (by amount of the debris generated at the connection between the CFR-PEEK plate and titanium alloy screws). The authors concluded that CFR-PEEK and metal implants yielded similar biomechanical characteristics to other commercially available devices. In particular, the distal volar plate bending structural stiffness of the CFR-PEEK distal volar plate was0.542 versus 0.376 N m2 for the DePuys DVR anatomic volar plate. All tested CFR-PEEK devices underwent one million fatigue cycles without failure. Moreover, the wear test showed that the accumulated debris on the 1 mm lters weighed very little, i.e. an average of 0.78 mg of the CF-PEEK material in comparison to 5.35 mg of the titanium sample [7].

Numerous studies documenting the successful clinical performance of CFR-PEEK in orthopedic, trauma and spinal surgery continue to emerge in the literature [810].

The research presented here represents the continuation of a previously reported study [11] with the aim to evaluate the clinical results at a 12-month follow-up, using the new DiPHOS-RM plate made of CFR-PEEK for the treatment of the distal radius fracture.

Materials and methods

We performed a prospective study including all patients who were treated for unstable distal radius fracture with a volar xed angle plate DiPHOS-RM produced by Lima Corporate (Villanova di San Daniele Del Friuli, Udine, Italy), during a period of 7 months (between March 2012 and September 2012). We included all the consecutive fractures of AO types B and C that remained displaced after an initial attempt at reduction. Fractures of AO type A were not included since they were treated nonsurgically. The patients were 16 men and 24 women with an average age of 65 years at the time of injury (range 2682). The

mechanisms of injury were simple falls on outstretched hands in 22 cases, motor vehicle accidents in 7 cases and sports injuries in another 11 cases. The fractures were classied according to the AO classication: 21 fractures were type C1, 9 were type C2, 2 were type C3, 2 were type B1 and 6 were type B2.

A preoperative computed tomography scan was carried out on all patients affected by type C fractures and in one patient a postoperative computed tomography scan was also obtained.

In this study, the researched plate (DiPHOS-RM, Lima corporate, Villanova di San Daniele, Italy) was manufactured by injection molding of CFR-PEEK and consists of two distal rows of holes for the 2.3 locking screws on the distal part of the plate, and three or more different holes for3.5 locked screws on the diaphysis (Fig. 1).

The main differences between a CFR-PEEK plate and

the most common materials in trauma implants (i.e. titanium plate) are the following:

The CFR-PEEK is completely radiolucent, a property that allows direct evaluation of osseous callus formation because consolidation and mineralization is not obscured by the plate in both standard views. The position of the plate can be detected anyway in the radiographic controls thanks to tantalum markers positioned on the distal and proximal borders.

The specic design of the holes of the CFR-PEEK plate and of the head of the screw allows the insertion of the screws in multiple directions with high strength coupling.

The threaded coupling between the head of the screw and the plate holes in the titanium angular stability plates could cause cold welding, while coupling of screws and plate of different materials precludes cold welding.

The elastic modulus of CFR-PEEK is similar to the modulus of the cortical bone, an advantageous feature for an osteosynthesis device, in order to prevent reduction of bone quality adjacent to the plate [12].

In order to reach a strong angular stability between plate and screws, the right choice of material and production process (injection molding) combined with a specic geometry of the holes of the plate and of the thread of the head of the screws was made.

The self-threading screws were inserted using the specic screwdriver according to the surgical technique in order to completely insert the screw into the hole of the plate.

The operations were performed using Henrys volar approach. The plate was placed directly on the radius after the reduction of the fracture, and the adequate positioning of plate and screws were conrmed by

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Fig. 1 3-D reconstruction of the new DiPHOS-RM plate and CT scan in 3-D showing an implanted plate in a C1-type fracture

intraoperative uoroscopy. Finally, the square pronator was sutured, allowing an almost complete coverage of the plate (Fig. 2).

A below-elbow wrist splint was used for 2 weeks in all cases. At the end of the 2nd week, the sutures were removed and physiotherapy started.

As we usually do in our clinical practice, all patients were clinically and radiologically revised at 1, 2, and 3 months, and thereafter at 6-monthly intervals.

The clinical and radiological evaluation was performed by one of the authors and included analysis of passive range of motion (ROM), grip strength, functional outcome, radiological evaluation of fracture healing and reduction maintenance.

The X-ray assessment included standard antero-posterior and lateral projections of the injured wrist, and reduction maintenance was determined by assessing radial inclination, tilt, ulnar variance, step off, and gap. All measurements were performed on a picture archiving and communication system (PACS, software Fuji Synapse).

Time of union was determined according to both radiological and clinical parameters. Radiological criteria included: bridging of the fracture site by bone, callus or trabeculae; bridging of the fracture seen at the cortices; and obliteration of the fracture line or cortical continuity. Clinical criteria were represented by the patients ability to bear weight on the injured limb and perform activities of daily living, and the presence of pain at the fracture site upon palpation and physical stress.

Clinical results were assessed with physician-directed outcome tools and with subjective questionnaires after surgery.

Grip strength was measured with a Jamar dynamometer (Asimov Engineering Corp, Santa Monica, CA), and wrist ROM using a goniometer. Functional outcome was performed with the Disabilities of Arm, Shoulder and Hand (DASH) questionnaire. This instrument quanties disabilities related to the upper extremity with a score ranging from 0 points (no disability) to 100 points (maximum disability) [13]. Possible early or late complications were assessed and recorded at each follow-up evaluation.

Results

At a 12-month follow-up all the patients included were clinically and radiologically reviewed.

Thirty-four patients who were in employment at the time of injury were able to return to work within 14 weeks of injury. All fractures healed, and radiographic union was observed at an average of 6 weeks (range 48 weeks). No cases of loss of the surgically achieved fracture reduction were documented. The clinical evaluation and outcome scores data at the nal follow-up are reported in Table 1. In particular, the average wrist range of motion was: 65 in exion (range 45 80 ), 55 in extension (range 40 65 ), 21.5 in radial deviation (range 5 35 ), 33.5 in ulnar deviation (range 30 45 ), 75 in supination (range 65 90 ), and 79 in pronation (range 60 90 ). The nal DASH score was 6

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Fig. 2 a Preoperative 2- and 3-D CT scan showing a C1-type wrist fracture according to the AO classication. b Intraoperative view of distal radius fracture with the DiPHOS-RM implanted and the

pronator quadratus re-attached. c X-ray evaluation performed 3 months after surgery showing good healing of the fracture

points (range 316). The average grip strength, expressed as percentage of respective contralateral limb, was 92 %. No cases of hardware failure, loss of position or alignment of xed-angle locking screws, nervous complications, infection or allergy to the plate were observed in our cohort of patients. In one case, a 55-year-old male, clinical signs of extensor tendons synovitis were reported 6 months after surgery. The diagnosis of extensor tenosynovitis was primarily based on the symptoms of pain, swelling, tenderness, and dorsal crepitus. Radiographs revealed an excessive length of one screw of the distal branch of the plate, after which the plate and the screws were removed. Intraoperative hardware osseointegration was found to be limited, facilitating, therefore, removal of the plate.

Discussion

The primary aim in the management of unstable distal radius fractures is to obtain restoration of bony anatomy with stable internal xation [14]. Secondary to its ability to provide stable internal xation of a distal radius fracture, volar locking plate technology has gained signicant popularity [15].

Numerous studies have reported outcomes in the good to excellent range on patient-rated scoring systems and with a relatively low rate of complications using volar plating as a treatment for unstable distal radius fractures [1621].

In the present study the overall clinical results obtained with the use of the new DiPHOS-RM plate at 12-month

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Table 1 Demographic characteristics, fracture type, clinical outcome and specic complications

Sex Age Fracture type/side ROM

Flexion ( ) Extension ( ) Supination ( ) Pronation ( ) Grip strength (%)a Complications

F 85 B2/left 80 60 70 85 90 NoneF 78 C1/right 45 45 80 80 80 NoneF 80 C1/left 50 60 75 80 100 NoneF 76 C1/right 45 55 65 70 90 NoneM 67 C1/right 75 50 65 75 80 NoneF 75 C2/right 60 60 80 85 100 NoneF 26 C1/right 55 50 85 90 65 NoneM 57 C1/left 70 45 75 80 95 NoneF 63 C3/left 50 50 65 75 95 NoneF 66 C2/right 55 55 70 80 100 NoneF 82 C1/right 65 55 65 75 80 NoneF 74 C1/left 60 65 70 75 90 NoneF 72 C1/left 70 60 85 80 95 NoneF 58 C1/left 65 60 70 85 100 NoneF 64 C1/right 75 50 75 85 85 NoneF 63 C2/right 60 45 65 70 80 NoneF 33 B2/left 60 50 80 75 100 NoneM 55 C1/left 80 60 90 75 100 Extensor tenosynovitis

M 59 B2/left 65 55 70 70 100 None F 59 C1/left 80 65 75 80 100 None F 65 C1/left 60 45 65 78 100 None F 64 B1/left 70 60 70 80 80 None F 63 C2/left 65 65 70 75 75 None M 63 B2/left 75 55 70 90 100 None M 60 C2/right 55 50 90 85 95 None M 77 C1/left 60 45 75 85 100 None M 57 C2/right 80 65 80 90 100 None M 60 C1/left 70 50 75 85 100 None F 63 C1/right 65 50 85 90 70 None M 72 C2/right 70 60 70 60 95 None M 68 C1/left 80 60 75 85 95 None M 75 C3/left 65 55 70 80 80 None F 58 C1/right 70 60 90 75 100 None M 82 C2/right 55 55 80 75 100 None F 77 C1/right 80 60 65 70 95 None M 56 C2/right 65 50 70 75 90 None M 80 B2/left 50 50 80 90 100 None F 54 C1/left 80 60 90 85 85 None F 63 B2/right 55 50 75 70 85 None M 59 B1/left 75 55 75 80 100 None

% Mean (SD) % Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) %

60 % F 40 % M

a Percentage obtained at nal evaluation when compared with contralateral side

65 (12) 5 % B1 15 % B2 52 % C1 23 % C2 5 % C3

65.2 (10.4) 54.9 (6.1) 74.9 (7.7) 79.3 (6.9) 91.7 (9.7) 2.5

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follow-up are consistent with the recent literature ndings using conventional metal plates [1621].

However, the CFR-PEEK structure of the DiPHOS-RM plate has potential advantages that may support its introduction into clinical practice.

Compared with traditional implants, such as stainless steel, CoCrMo, and Ti6A14 V alloy stainless steel or titanium plates, PEEK polymer has a modulus and strengths similar to normal bone, avoiding the strong rigidity property of titanium or stainless steel plates [12, 22].

Typically, metals used in orthopedic surgery have a large elastic modulus (approximately 620 times greater than that of the surrounding bone) [2325], causing impaired load force transmission at the implanttissue interface.

Thus, according to Wolffs law, the device may sustain far higher stresses than the bone to which it is rigidly xed, thereby shielding the bone for stresses. Because bone requires the stimulus of mechanical stress to maintain its structure, the bone adjacent to the high modulus device becomes porotic and weaker [26, 27].

Another advantage of using a PEEK plate with metal screws is that the potential phenomenon of cold welding is eliminated. Moreover, this new plate allows in its distal part both the insertion of xed-angle screws or distally locked screws at variable angles and with an angular range of 15 by deciding whether or not to use the provided guide. Finally, the major advantage of the DiPHOS-RM plate is its radiolucency. This characteristic allows direct visualization of osseous callus formation, allowing monitoring of the healing of the fracture, thereby improving clinical assessment and accuracy.

Therefore, specic indications for this new radiolucent plate can be represented by fractures with signicant metaphyseal comminution and in cases of nascent malunion where a distal radius osteotomy with bone grafting is usually performed to correct the wrong angle.

In our cohort of patients we havent found any complications related to the new material of the implant, but particular care and attention is necessary while inserting the screws, as the holes of the plate are not threaded. The penetration of the screw into the hole of the plate creates a thread, allowing locking of the screws, but no more than three changes of angle is possible before the thread is ruined.

In our cohort of patients, no cases of hardware breakage, loss of the surgically achieved fracture reduction, or allergy to the plate were documented at a 12-month follow-up. The hardware was removed only in one case (5 %) for the occurrence of extensor tenosynovitis after a screw penetrated the dorsal radius cortex.

In this research we observed a limited osseointegration of this hardware, probably allowing, when necessary, an

easier removal of the plate with respect to the other routinely used materials.

Compared with stainless steel or titanium plates, the cost of production of this implant is higher but the commercial price is in line with that of the metal systems.

Our rst experience of using the new DiPHOS-RM plate seems favorable: in fact the plate proved to be a reliable method with good clinical and functional results at a 12-month follow-up. In addition, its distal double-row screw system and its far positioning within the distal radius epiphysis resulted in a reliable support for the articular surface, allowing maintenance of reduction even in cases of comminuted intra-articular fractures (i.e. C-type).

Future studies with a larger sample size are needed to evaluate the long-term clinical results and occurrence of possible complications at a longer follow-up using this new CFR-PEEK plate.

Conict of interest None.

Ethical standards (1) The patients gave informed consent prior to being included in the study, (2) the study was authorized by the local ethical committee and was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki as revised in 2000.

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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