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Abstract [ Objective] To investigate the antifungal effect of essential oils from 5 medicinal herbs on Candida albicans. [Method] By adopting tube disk approach , the essential oils of cinnamon bark , palchouli , clove , fennel and Schisandra rosea were respectively diluted to 2.50. 019 5 µL/mL by tiraes ratio dilution for MIC and MFC experiments on pathogenic Candida albicans strains ( Monilia albican, Candida tropical, Candida krusei) from intestinal tract, lung and kidney. [ Results] The MIC and MFC of cinnamon bark oil against Candida albicans were 0. 039 and 0. 078 µL/mL respectively; those of clove oil against Candida albicans were 0. 156 and 0. 312 5 µl/mL respectively; those of palchouli oil against Candida albicans were 0. 313 and 0. 625 µL/mL respectively; those of fennel oil oil against Candida albicans were 0. 156 and 0.312 5 µL/mL respectively. The MIC of Schisandra rosea oil against Candida albicans ( Monilia albican, Candida krusei) was 0. 312 5 µL/mL, that against Candida tropical was 0. 625 µL/mL, and the MFC oí Schisandra rosea oil against Candida albicans was 0. 312 5 µ?/mL. For the control group (fluconazole), the MIC oí Schisandra rosea oil against Candida albicans ( Monilia albican, Candida tropical) was 0.312 5 µL/mL, and that against Candida krusei was 2.5 mg/mL. The essential oils from five medicinal herbs all showed strong antifungal effect against Candida albicans strains (Monilia albican, Candida tropical, Candida krusei). The antifungal activity was determined in turn as cinnamon bark oil > clove oil > palchouli oil > fennel oil > Schùandra rosea oil. Candida krusei showed drug resistance to fluconazole. [ Conclusion] The essential oils extracted from natural medicinal herbs are effective in treating invasive fungal infection caused by Candida albicans, moreover, this does not bring drug resistance to Candida albicans.
Key words Cinnamon bark oil; Palchouli oil; Clove oil iFennel oil; Schisandra rosea oil; Candida albicans; In vitro antifungal activity
1 Preface
With the broad application of wide-spectrum antibiotic , corticosteroid and immune inhibitor, invasive fungal infection has appeared clinically more and more in various subjects, which has become the complication heavily endangering high risk patients. It is the main cause of hematonosis, tumor, pulmonary fungal infections and acquired immuno deficiency syndrome (...